Chemical name: Crosslinked Polyvinylpyrrolidone

CAS accession number: 25249-54-1

Specifications:

Appearance：white or white-like powder

Chemical formula： (C6H9NO)n 

Molecular weight ：111.142 

Density  g/cm3： 1.144 

Melting point  ℃： 300 

Boiling point  ℃ ：217.6 

Refractive index： 1.593 

Moisture  % ≤： 6.0 

Water- soluble matter  % ≤ ： 0.5 

Free-N-vinylpyrrolidone ppm  ≤ ：10 

N,N-divinyl-imidazolinone ppm  ≤  ：  2 

PH(in 1% water)：5-8 

Heavy metal   ppm ≤ ：10 

Nitrogen content  % ：11.0-12.8 

Sulphated Ash  % ≤  ：0.4 

peroxide  ppm ≤： 400 

◆Nature:white or nearly white, hygroscopic and easy-to-flow powder, odorless or slightly smelly, insoluble in water, strong alkali,strong acid and common organic solvents such as ethanol, chloroform or ether, with very light expansion, Excellent physiological inertness,biocompatibility and good complexation ability with various substances.

◆Application:Disintegrating agents commonly used in the pharmaceutical industry are insoluble PVPP, hydroxymethyl starch and L-hydroxypropyl cellulose. The decomposition effect of insoluble PVPP tablets is the most obvious and convenient. Because the swelling of insoluble PVPP is reversible, it is not affected by pre-wetting and drying, and its effect and decomposition time are not affected;

can also be used as disintegrant and filler for pills, granules, hard capsules.

◆Storage method:should be sealed and stored in a clean and dry warehouse, and attention should be paid to fire prevention,waterproof, sun protection, dust prevention and pollution prevention.

　　PVPP (Pharmaceutical grade) function:

　　A disintegrator for tablets

　　Disintegrators and fillers for pills, granules and hard capsules

　　Complexing agent and co-solvent

　　Hemodialysis membrane

　　Trauma wrap

　　Artificial vitreous body

　　It can be used as a disintegrating agent and filler for drug sustained-release carrier, pill, granule and hard capsule. In addition, it is widely used as suspension stabilizer, drug component complexing agent, and complexing agent of tannins and polyphenols in botanical drugs.

　　Hemodialysis membrane: has good blood compatibility, can specifically remove opioid narcotic drugs, used for hemoperfusion, remove toxins from the blood.

　　PVPP hydrogel is a spongy loose substance produced after drying, which can be used as a trauma wrapping tape. Absorb liquid, through the air but can shield bacteria, absorb and release drugs, tape is soft but has a certain mechanical strength; Research on vitreous fluid substitutes for eyeballs has been carried out.

　　PVPP production process

　　Depending on the degree of crosslinking, PVPP can appear as super absorbent resins (low crosslinking), water absorbent gels (medium crosslinking), and insoluble substances (high crosslinking).

　　Polyvinylpyrrolidone (PVP) crosslinking method: By treating PVP with persulfate, hydrazide, hydrogen peroxide or crosslinking agents (such as NMBA, EVP, etc.), PVPP with moderate crosslinking degree can be obtained, which is a water-absorbent gel.

　　N-vinylpyrrolidone (NVP) self-crosslinking polymerization method: NVP in the presence of alkali metal hydroxide, temperature above 100℃, self-crosslinking polymerization method to obtain a high degree of cross-linked water insoluble PVPP.

　　Cross-linking agent and NVP monomer copolymerization method: In the case of bifunctive compound as crosslinking agent, cross-linking copolymerization with NVP monomer can obtain PVPP with low crosslinking degree and super water absorption and water retention ability.

　　PVPP product price 78 yuan -90 yuan/kg, the price fluctuates every month, please consult Shanghai art letter customer service for details.